性别：男

 所属部门：线粒体遗传与健康研究中心   

    职称：资深研究员

 电子邮箱：guzhenglong@ipm-gba.org.cn   

    学历：博士

 研究方向：线粒体DNA突变与疾病

个人介绍

顾正龙教授，国际知名遗传学家，现任粤港澳大湾区精准医学研究院助理院长、线粒体遗传与健康研究中心主任、复旦大学特聘教授。1998年获得北京大学学士学位，2003年获得芝加哥大学博士学位。2006年于康奈尔大学任教，2018年晋升为终身正教授。获得多项NIH、NSF等资助，荣获华盛顿国际生命研究院 2011 年“营养学未来领袖”奖。在多种顶级国际学术期刊上发表文章逾60余篇，包括Nature、Nature Genetics、PNAS、Genome Research、FASEB、MBE、JBC等，引用总计超 4800次。

研究方向

· 开发线粒DNA体测序方法及遗传操作工具；

· 研究线粒DNA突变在衰老及相关疾病中的作用机制；

· 开发基于线粒体功能的延缓衰老，预防疾病的新方法。

论文

1. Wang, Y., et al., Reducing embryonic mtDNA copy number alters epigenetic profile of key hepatic lipolytic genes and causes abnormal lipid accumulation in adult mice. FEBS J, 2021.

2. Wang, Y., et al., Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington's disease. Proc Natl Acad Sci U S A, 2021. 118(30).

3. Guo, X., et al., Understand the genomic diversity and evolution of fungal pathogen Candida glabrata by genome-wide analysis of genetic variations. Methods, 2020. 176: p. 82-90.

4. Guo, X., et al., STAMP: a multiplex sequencing method for simultaneous evaluation of mitochondrial DNA heteroplasmies and content. NAR Genom Bioinform, 2020. 2(4): p. lqaa065.

5. Yang, X., et al., Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy. Annu Rev Nutr, 2019. 39: p. 201-226.

6. Wang, Z., et al., Novel insights into global translational regulation through Pumilio family RNA-binding protein Puf3p revealed by ribosomal profiling. Curr Genet, 2019. 65(1): p. 201-212.

7. Si, Y., et al., Glucomannan Hydrolysate Promotes Gut Proliferative Homeostasis and Extends Life Span in Drosophila melanogaster. J Gerontol A Biol Sci Med Sci, 2019. 74(10): p. 1549-1556.

8. Zhang, R., et al., Independent impacts of aging on mitochondrial DNA quantity and quality in humans. BMC Genomics, 2017. 18(1): p. 890.

9. Cheng, J., et al., Parallel Evolution of Chromatin Structure Underlying Metabolic Adaptation. Mol Biol Evol, 2017. 34(11): p. 2870-2878.

10. Zhang, R., et al., Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma. Sci Rep, 2016. 6: p. 36097.

11. Wang, Y., M. Picard, and Z. Gu, Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder. PLoS Genet, 2016. 12(10): p. e1006391.

12. Kothapalli, K.S., et al., Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid. Mol Biol Evol, 2016. 33(7): p. 1726-39.

13. Ye, K., et al., Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals. Proc Natl Acad Sci U S A, 2014. 111(29): p. 10654-9.

14. Xu, L., B. Barker, and Z. Gu, Dynamic epistasis for different alleles of the same gene. Proc Natl Acad Sci U S A, 2012. 109(26): p. 10420-5.

15. Jiang, H., et al., Rewiring of posttranscriptional RNA regulons: Puf4p in fungi as an example. Mol Biol Evol, 2012. 29(9): p. 2169-76.

16. Ye, K. and Z. Gu, Recent advances in understanding the role of nutrition in human genome evolution. Adv Nutr, 2011. 2(6): p. 486-96.

17. Jiang, H., W. Guan, and Z. Gu, Tinkering evolution of post-transcriptional RNA regulons: puf3p in fungi as an example. PLoS Genet, 2010. 6(7): p. e1001030.

18. Jiang, H., et al., Relaxation of yeast mitochondrial functions after whole-genome duplication. Genome Res, 2008. 18(9): p. 1466-71.

19. Gu, Z., et al., Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 2005. 102(4): p. 1092-7.

20. Gu, Z., et al., Duplicate genes increase gene expression diversity within and between species. Nat Genet, 2004. 36(6): p. 577-9.

21. Gu, Z., et al., Role of duplicate genes in genetic robustness against null mutations. Nature, 2003. 421(6918): p. 63-6.

22. Li, W.H., et al., Evolutionary analyses of the human genome. Nature, 2001. 409(6822): p. 847-9.