粤港澳大湾区精准医学研究院

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细胞治疗与免疫治疗研究中心|王华伟

发布日期:2022-01-28 15:26:30 作者: 来源:

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   性别:男所属部门:细胞治疗与免疫治疗研究中心   职称:青年研究员电子邮箱:wanghuawei@ipm-gba.org.cn   学历:博士


个人介绍

中科院遗传与发育生物学研究所博士,曾任加州大学圣地亚哥分校医学院病理系博士后及助理研究科学家,于2021年11月全职加入粤港澳大湾区精准医学研究院(广州),担任细胞治疗与免疫治疗研究中心青年研究员、课题组长,组建精准递送与免疫治疗实验室(Laboratory of Precision Delivery and Immunotherapy)。

王华伟博士在发育生物学,癌症生物学,细胞工程与肿瘤免疫治疗等方面积累了丰富的研究经验,曾在Nature Biomedical Engineering, Cancer Research, Cell Discovery, PNAS, Nature Communication等重要学术期刊发表过多篇学术论文,申请了多项美国与中国专利并且成功获得了授权与转化。本课题组将与复旦大学林鑫华教授团队紧密合作,聚焦于可编程精准递送载体的研究,利用复旦大学遗传工程国家重点实验室的多个平台例如类器官研究平台,主要针对重大人类疾病例如扩散型恶性肿瘤,开发免疫疗法与细胞疗法的新策略。

本课题组长期招聘博士后,欢迎热爱生物医学研究、有想法、有冲劲的青年学者加入!


研究方向

· 新型可编程精准递送载体

· 细胞治疗与细胞工程

· 恶性肿瘤的免疫治疗新策略


代表性论文专著



· Wang H*, Alarcón C*, Liu B, Watson F, Searles S, Lee C, et al. Wang, H., Alarcón, C.N., Liu, B. et al. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Nature Biomedical Engineering (2021). (* Co-first author)

· Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, et al. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discovery. 2018;4:26.

· Fujimura K*, Wang H*, Watson F, Klemke RL. KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. Cancer Research. 2018;78:1444-56. (*Co-first author)

· Strnadel J*, Wang H*, Carromeu C, Miyanohara A, Fujimura K, Blahovcova E, et al. Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos. Journal of Molecular Neuroscience. 2018;65:351-8. (*Co-first author)

· Yang L, Jama B, Wang H, Labarta-Bajo L, Zuniga E. I., and Morris G. P. TCRalpha reporter mice reveal contribution of dual TCRalpha expression to T cell repertoire and function. Proc Natl Acad Sci U S A 117, 32574-32583.

· Noriega-Guerra H, Cruz MC, Ribeiro PRL, Strnadel J, Wang H, Klemke RL, et al. ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. Exp Cell Res. 2018;363:271-82.

· Liu C, Han TX, Stachura DL, Wang H, Vaisman BL, Kim J, et al. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Communication. 2018;9.

· Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, et al. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018;8:2982.

· Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, et al. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017;77:1997-2007.

· Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, et al. Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biology of Reproduction. 2016;95:67.

· Wang H, Fang JS, Kuang X, Miao LY, Wang C, Xia GL, et al. Activity of Long-Chain Acyl-CoA Synthetase Is Required for Maintaining Meiotic Arrest in Xenopus laevis. Biology of Reproduction. 2012;87.


专利

· Platform For Generating Safe Cell Therapeutics. 美国专利号码: US 10,927,349 B2. 已于2021年2月23日获得美国国家专利局授权。 国际专利号码: WO 2019/032628 A1. 根据本发明成立的生物技术公司Cytonus Therapeutics已经获得了近千万美元的融资和多项美国国立健康研究院的基金资助。  

· Methods and Use for Bioengineering Enucleated Cells. 国际专利申请号: WO 2021/158991 A1.

· 一种酵母基因工程菌及β-甘露聚糖酶制剂和甘露低聚糖的生产方法.   中国专利号: CN 1478887 A. 授权日期: 2004年3月2号.

 

项目

· 04/25/19-04/30/20   课题负责人 资助方:乐天医疗. “Immunology analysis and profiling of patient samples from a clinical trial”

· 12/19/18-12/20/19    共同课题负责人 资助方:加州大学药物创新中心. “Development of a Novel Cell Vehicle for Delivery of Oncolytic Virus to Treat Metastatic PDAC”

· 参与美国国立癌症研究所的多个重要基金项目:1R41CA250887-01(06/15/20-05/31/21);1R41CA257020-01(09/01/20-08/31/21);R01 CA182495-01A1(09/01/14-08/31/20);R01 CA182495-01A1(09/01/14-08/31/20);R01 CA184594-03(04/03/14-02/28/19);R01 CA097022-14 (07/01/02-02/28/18)。

 

其它

· 2019 Travel Award for the 22nd annual meeting of American Society of Gene & Cell Therapy, Washington D.C., the U.S.

· 2016 Associate Faculty Member, Faculty of 1000.

· 2014 Travel Award for the 16th International Symposium on Anti-Angiogenic Therapy: Recent Advances and Future Directions in Basic and Clinical Cancer Research, San Diego, the U.S.



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