性别：男

 所属部门：线粒体遗传与健康研究中心   

    职称：青年研究员

 电子邮箱：puweilin@ipm-gba.org.cn   

    学历：博士

 研究方向：皮肤及其附属器疾病的组学研究

个人介绍

  2018年博士毕业于复旦大学，2018-2022年于复旦大学王久存教授课题组进行博士后研究，主要研究领域为复杂疾病的遗传和表观遗传学发病机制研究。2022年7月加入粤港澳大湾区精准医学研究院（广州）线粒体遗传与健康研究中心，并担任青年研究员（Co-PI）。本人博士后期间曾获得上海市“超级博士后”计划和复旦大学“超级博士后”计划资助，以第一或共同第一作者在Annals of Rheumatic Diseases, Nature Communications, Journal of Investigative Dermatology 等国际知名杂志发表论文14篇。

研究方向

  课题组主要方向为利用高通量组学技术，包括基因组、表观组、转录组、单细胞组学等，结合临床样本及功能实验平台，从遗传和代谢角度探索皮肤及其附属器疾病的发病机制。目前研究兴趣主要集中在：

  1.评估线粒体在皮肤纤维化疾病中的关键作用；

  2.探索雄激素秃发疾病的特征及关键分子事件。

发表论文

1.Pu W#, Shi X#, Yu P#, Zhang M#, Liu Z, Tan L, Han P, Wang Y, Ji D, Gan H, Wei W, Lu Z, Qu N, Hu J, Hu X, Luo Z, Li H, Ji Q, Wang J, Zhang X*, Wang Y*. Single-cell Transcriptomic Analysis Reveals the Landscape of Tumor Ecosystems Underlying Initiation and Progression of Papillary Thyroid Carcinoma. Nat Commun. 2021 Oct 18;12(1):6058. (IF = 14.9)

2.Pu W#, Zhang R#, Ma Y, Liu Q, Jiang S, Liu J, Zhao Y, Tu W, Guo G, Zuo X, Wang Q, Chen Y, Wu W, Zhou X, Distler JW, Reveille JD, Zou H, Jin L, Mayes MD, Wang J*. Genetic associations of non-MHC susceptibility loci with systemic sclerosis in a Han Chinese population. J Invest Dermatol. 2022 Jul;142(7):2039-2042.e7. (IF = 8.6)

3.Pu W#, Wu W#, Liu Q#, Ma Y#, Tu W#, Zuo X#, Guo G#, Jiang S, Zhao Y, Zuo X, Wang Q, Yang L, Xiao R, Chu H, Wang L, Sun L, Cui J, Yu L, Li H, Li Y, Shi Y, Zhang J, Zhang H, Liang M, Chen D, Ding Y, Chen X, Chen Y, Zhang R, Zhao H, Li Y, Qi Q, Bai P, Zhao L, Reveille JD, Mayes MD, Jin L, Lee EB, Zhang X, Xu J, Zhang Z, Zhou X, Zou H, Wang J*. Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in the Han Chinese Population. J Invest Dermatol. 2021 May;141(5):1254-1263.e6. (IF = 8.6)

4.Pu W#, Qian F#, Liu J, Shao K, Xiao F, Jin Q, Liu Q, Jiang S, Zhang R, Zhang J, Guo S, Zhang J, Ma Y*, Ju S*, Ding F*. Targeted bisulfite sequencing reveals DNA methylation changes in zinc finger family genes associated with KRAS mutated colorectal cancer. Front Cell Dev Biol. 2021; 9:759813. (IF = 6.7)

5.Pu W#, Wang C#, Chen S, Zhao D, Zhou Y, Ma Y, Wang Y, Li C, Huang Z, Jin L, Guo S*, Wang J*, Wang M*. Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC). Clin Epigenetics. 2017 Dec 15;9:129. (IF = 6.6)

6.Pu W#, Geng X#, Chen S, Tan L, Tan Y, Wang A, Lu Z, Guo S*, Chen X*, Wang J*. Aberrant methylation of CDH13 can be a diagnostic biomarker for lung adenocarcinoma. J Cancer. 2016 Nov 25;7(15):2280-2289. (IF = 4.2)

7.Liu J#, Pu W#, Li Y, Ma Y, Zhu Q, Wan W, Yang C, Wang X, Chen X, Zhou X, Reveille JD, Jin L, Zou H*, Wang J*. Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population. Ann Rheum Dis. 2019 Jun;78(6):852-853. (IF = 19.1)

8.Ding W#, Pu W#, Wang L#, Jiang S, Zhou X, Tu W, Yu L, Zhang J, Guo S, Liu Q, Ma Y, Chen S, Wu W, Reveille J, Zou H, Jin L, Wang J*. Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of interferon-associated genes in CD4+ and CD8+ T cells. J Invest Dermatol. 2018 May;138(5):1069-1077. (IF = 8.6)

9.Ding W#, Pu W#, Jiang S, Ma Y, Liu Q, Wu W, Chu H, Zou H, Jin L, Wang J*, Zhou X*. Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3. EBioMedicine. 2018 Dec;38:238-247. (IF = 8.1)

10.Shao K#, Pu W#, Zhang J#, Guo S, Qian F, Glurich I, Jin Q, Ma Y, Ju S, Zhang Z*, Ding W*. DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter. Clin Epigenetics. 2021 Apr 23;13(1):89. (IF = 6.6)

11.Guo S#, Tan L#, Pu W#, Wu J, Xu K, Wu J, Li Q, Ma Y, Xu J, Jin L*, Wang J*. Quantitative assessment of the diagnostic role of APC promoter methylation in non-small cell lung cancer. Clin Epigenetics. 2014 Mar 24;6(1):5. (IF = 6.6)

12.Wang C#, Pu W#, Zhao D, Zhou Y, Lu T, Chen S, He Z, Feng X, Wang Y, Li C, Li S, Jin L, Guo S*, Wang J*, Wang M*. Identification of Hyper-Methylated Tumor Suppressor Genes-Based Diagnostic Panel for Esophageal Squamous Cell Carcinoma (ESCC) in a Chinese Han Population. Front Genet. 2018 Sep 5;9:356. (IF = 4.6)

13.Hao M#, Pu W#, Li Y#, Wen S#, Sun C, Ma Y, Zheng H, Chen X, Tan J, Zhang G, Zhang M, Xu S, Wang Y*, Li H*, Wang J*, Jin L*. The HuaBiao Project: Whole-Exome Sequencing of 5,000 Han Chinese Individuals. J Genet Genomics. 2021;48(11):1032-1035. (IF = 4.3)

14.Liu J#, Tang Y#, Huang Y#, Gao J, Jiang S, Liu Q, Ma Y, Qian X, Qian F, Reveille J, He D, Zou H, Jin L, Zhu Q*, Pu W*, Wang J*. Single-cell analysis reveals innate immunity dynamics in Ankylosing Spondylitis. Clin. Transl. Med. 2021;11(3):e369. (IF = 11.5)

主持及参与项目

1、主持国自然青年项目、中国博士后面上项目；

2、作为科研骨干参与国家自然科学基金重点项目”铁代谢紊乱在肺纤维化中的作用及分子机制”、中国科学院院外创新单元等重大科技项目。