性别：女

 所属部门：智能医学研究中心   

    职称：青年研究员

 电子邮箱：jingying@ipm-gba.org.cn   

    学历：博士

 研究方向：肿瘤免疫计算生物学 

个人介绍

  景莹，2014年博士毕业于复旦大学，2018-2020年在美国德州大学休斯顿健康科学中心完成博士后训练。2021-2023年曾任上海交通大学医学院副研究员。2023年全职加入粤港澳大湾区精准医学研究院智能医学研究（广州）担任课题组组长。在国际知名期刊共发表论文40篇，总引用量逾1300次，其中代表性研究成果发表于Nature Review Clinical Oncology, Cancer Cell, Nature Communications等国际知名期刊。曾获上海市海外高层次人才和浦江人才称号。

  课题组致力于用生物信息学、肿瘤分子生物学和免疫学交叉的方法来研究免疫介导的抗肿瘤药物副作用，解析免疫相关副作用的发生机制及其和抗肿瘤免疫反应之间的关系，开发特异性预测最小免疫相关副作用和最大疗效的模型，从而实现肿瘤患者临床获益的最大化。

  欢迎对肿瘤免疫感兴趣的的青年学者加入！

研究方向

   1.开发抗肿瘤药物毒性预测模型

   2.鉴定免疫相关副作用的特征性免疫调节因子

   3.基于多维度大数据探索潜在的副作用风险低的抗肿瘤药物靶标

代表性论文著作

1. Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss.

Xiaoqi Yu, Qiming Gong, Demin Yu, Yongyan Chen, Ying Jing*, Fabien Zoulim*, Xinxin Zhang*. Gut. 2023 Nov 15:gutjnl-2023-330577.

2. Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma.

Minjiang Chen#, Pengfei Ma#, Yongchang Zhang#, Dong Wang#, Zhuang Yu, Yujie Fu , Xiaojing Zhao, Mengzhao Wang*, Guanglei Zhuang*, Ying Jing*. J Immunother Cancer. 2023 Oct;11(10):e007305.

3. Single-Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural-Like Progenitor Program Associated with the Efficacy of Radiotherapy.

Lei Zhang, Jun Ma, Di Zhou, Junjun Zhou, Bin Hu, Xiumei Ma, Jianming Tang*, Yongrui Bai*, Haiyan Chen*, and Ying Jing*. Advanced Science, 2023 Sep;10(25):e2300348.

4. Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events.

Ying Jing*, Jingwen Yang, Leng Han*. Cell Report Medicine, 2023 Jan 17;4(1):100902.

5. Advancing CAR T-cell therapy through multi-dimensional omics data.

Jingwen Yang#, Yamei Chen#, Ying Jing#, Michael R. Green*, Leng Han*. Nature Review Clinical Oncology, 2023 Jan 31

6. Harnessing big data to characterize immune-related adverse events.

Ying Jing#, Jingwen Yang#, Douglas B Johnson*, Javid J Moslehi*, Leng Han*. Nature Review Clinical Oncology, 2022 Apr;19(4):269-280;

7. Association of antibiotic treatment with immune-related adverse events in cancer patients receiving immunotherapy.

Ying Jing#, Xue Chen#, Kunyan Li#, Yaoming Liu, Zhao Zhang, Yiqing Chen, Yuan Liu, Yushu Wang, Steven H. Lin, Lixia Diao, Jing Wang, YanYan Lou, Douglas B. Johnson, Xiang Chen*, Hong Liu*, Leng Han*. Journal for Immunotherapy of Cancer, 2022, 10(1): e003779

8. Expression of chimeric antigen receptor therapy targets in subpopulations detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.

Ying Jing#*, Yuan Liu#, Qiang Li, Youqiong Ye, Lixia Diao, Yun Huang, Yubin Zhou, Michael R Green, Gordon B. Mills, Leng Han*. Cancer Cell, 2021 Dec 13; 39(12):1558-1559

9. Association between sex and immune-related adverse events during immune checkpoint inhibitor therapy.

Ying Jing#, Yongchang Zhang#, Youqiong Ye, Yaoming Liu, Yanyan Lou, Steven H. Lin, Lixia Diao, Hong Liu, Gordon B. Mills*, Leng Han*. Journal of the National Cancer Institute, 2021 Mar 10; djab035

10. Adverse events associated with potential drugs for COVID-19: a case study from real-world data.

Ying Jing*, Lixia Diao*, Leng Han*. Briefings in bioinformatics, 2021 Mar 22; 22(2):1232-1238

11. Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy.

Ying Jing#, Jin Liu#, Youqiong Ye, Lei Pan, Hui Deng, Yushu Wang, Yang Yang, Lixia Diao, Steven H. Lin, Gordon B. Mills, Guanglei Zhuang*, Xinying Xue*, Leng Han*. Nature Communications, 2020 Oct 2; 11(1):4946

12. Baseline immunity and impact of chemotherapy on immune microenviroment in cervical cancer.

Yi Zhang#, Minhua Yu#, Ying Jing#, Jiejun Cheng, Caiyan Zhang, Lin Cheng, Haijiao Lu, Mei-chun Cai, Jie Wu, Wenjing Wang, Weihua Lou, Lihua Qiu, Li Tan, Huaiwu Lu, Xia Yin, Guanglei Zhuang*, Wen Di*. British Journal of Cancer, 2021 Jan; 124(2):414-424

13. Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancer.

Ying Jing#, Yi Zhang#, Hui Zhu#, Ke Zhang, Mei-Chun Cai, Pengfei Ma, Peiye Shen, Zhenfeng Zhang, Minghui Shao, Jing Wang, Minhua Yu, Xia Yin, Meiying Zhang, Yuan Hu, Danni Chen, Wen Di, Xiaojie Wang*, Guanglei Zhuang*. Oncogene, 2019 April; 38(16):3047-3060

14. Prevalence and clonality of synchronous primary carcinomas in the bladder and prostate.

Ying Jing#, Ruiyun Zhang#, Pengfei Ma, Mei-Chun Cai, Guanglei Zhuang*, Haige Chen*. Journal of Pathology, 2018 Jan; 244(1):5-10

15. Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics.

Peiye Shen#, Ying Jing#, Ruiyun Zhang#, Mei-chun Cai, Pengfei Ma, Haige Chen*, Guanglei Zhuang*. Oncogene, 2018 May; 37(22):3039-3044

16. Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.

Shengzhe Zhang#, Meiying Zhang#, Ying Jing#, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang*. Nature Communications, 2018 Jan; 9(1):215

17. Clonality, heterogeneity and evolution of synchronous bilateral ovarian cancer.

Xia Yin#, Ying Jing#, Mei-Chun Cai#, Pengfei Ma, Yi Zhang, Cong Xu, Meiying Zhang, Wen Di*, Guanglei Zhuang*. Cancer Research, 2017 Dec 1; 77(23):6551-6561

18. BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by downregulating FoxM1.

Zhenfeng Zhang#, Pengfei Ma#, Ying Jing#, Ying Yan, Mei-chun Cai, Meiying Zhang, Shengzhe Zhang, Huixin Peng, Zhi-liang Ji, Wen Di, Zhenyu Gu, Wei-Qiang Gao*, Guanglei Zhuang*. Theranostics, 2016; 6(2):219-30

19. Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex.

Deshui Jia#, Rui Dong#, Ying Jing#, Dan Xu#, Qifeng Wang, Lei Chen, Qigen Li, Yuping Huang, Yuannv Zhang, Zhenfeng Zhang, Li Liu, Shan Zheng, Qiang Xia, Hongyang Wang, Kuiran Dong*, Xianghuo He*. Hepatology, 2014; 60(5): 1686-9

20. SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma.

Ying Jing#, Deshui Jia#, Chun-Ming Wong, Irene Oi-Lin Ng, Zhenfeng Zhang, Li Liu, Qifeng Wang, Fangyu Zhao, Jinjun Li, Ming Yao, Xingzhong Wu*, Xianghuo He*. Molecular Oncology, 2014; 8(2):366-77