性别：男

所属部门：原创新药中心

职称：研究员

电子邮箱：cuijin@ipm-gba.org.cn

学历：博士

个人介绍 

    2015年于日本大阪大学获化学博士学位； 2015-2017年获日本学术振兴会（JSPS）特别研究员基金资助，在日本微生物化学研究所从事博士后研究工作，随后获终身职位留所工作，先后任研究员、高级研究员、主任研究员；2023年加盟粤港澳大湾区精准医学研究院（广州）并担任研究员、课题组组长。课题组致力于天然产物全合成、多肽化学生物学和不对称催化合成等领域。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Proc. Natl. Acad. Sci. USA. 、Chem. Sci. 等杂志发表论文二十余篇，主持和完成了多项日本国家级基金项目。

   本课题组长期招聘博士后，诚挚欢迎优秀青年学者加入团队!

研究方向

  1.天然产物全合成

  2.多肽化学生物学

  3.不对称催化合成

代表性论文专著

1.Samanta, S.; Cui, J.*; Otsuka, Y.; Watanabe, T.*; Shibasaki, M.* Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates. Org. Lett. 2024, 26, 2255.

2.Cui, J.*; Oriez, R.; Samanta, S.; Noda, H.*; Watanabe, T.; Shibasaki, M.* Catalytic Asymmetric Vinylogous Conjugate Addition of Butenolide to 2-Ester-Substituted Chromones: Access to Chiral Chromanone Lactones via Trapping of a Copper(I) Enolate by Trimethyl Borate. Org. Lett. 2023, 25, 8367.

3.Cui, J.*; Samanta, S.; Watanabe, T.; Shibasaki, M.* Brønsted Base-Catalyzed Direct 1,6-Conjugate Addition of Butenolide to p-Quinone Methides. Asian J. Org. Chem. 2023, 12, e202300176.

4.Samanta, S.; Cui, J.; Noda, H.; Watanabe, T.; Shibasaki, M. Asymmetric syn-selective vinylogous addition of butenolides to chromones via ALB catalysis. J. Org. Chem. 2022, 88, 1177.

5.Cui, J.; Ogasawara, Y.; Kurata, I.; Matoba, K.; Fujioka, Y.; Noda, N. N.; Shibasaki, M.; Watanabe T. Targeting the ATG5-ATG16L1 protein-protein interaction with a hydrocarbon-stapled peptide derived from ATG16L1 for autophagy inhibition. J. Am. Chem. Soc. 2022, 44, 38, 17671. Selected as Supplementary Cover

6.Cui, J.*; Oriez, R.; Noda, H.; Watanabe, T.; Shibasaki, M.* Concise and stereodivergent approach to chromanone lactones through copper-catalyzed asymmetric vinylogous addition of siloxyfurans to 2-ester-substituted chromones. Angew. Chem. Int. Ed. 2022, 61, e202203128. Selected as Inside Back Cover

7.Cui, J.; Kumagai, N.; Watanabe, T.; Shibasaki, M. Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones. Chem. Sci. 2020, 11, 7170. Highlighted in Synfacts 2020, 16, 1079.

8.Yamagami, M.; Tsuchikawa, H.; Cui, J.; Umegawa, Y.; Miyazaki, Y.; Seo, S.; Shinoda, W.; Murata, M. Average conformation of branched-chain lipid PGP-Me that accounts for the thermal stability and high-salinity resistance of archaeal membranes. Biochemistry, 2019, 58, 37,3869.

9.Cui, J.; Ohtsuki, A.; Watanabe, T.; Kumagai, N.; Shibasaki, M. Direct catalytic asymmetric aldol reaction of thioamide with an α‐vinyl appendage. Chem. Eur. J. 2018, 24, 2598. Highlighted in Synfacts 2018, 14, 0383.

10.Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M. Leptolyngbyolides, cytotoxic macrolides from the marine cyanobacterium leptolyngbya sp.: isolation, biological activity, and catalytic asymmetric total synthesis. Chem. Eur. J. 2017, 23, 8500.

11.Sahara, Y.; Cui, J.; Furutachi, M.; Chen, J. B.; Watanabe, T.; Shibasaki, M. Catalytic asymmetric synthesis of the C1-C15 segment of spirastrellolide A. Synthesis 2017, 49, 69.

12.Cui, J.; Watanabe, T.; Shibasaki, M. Catalytic asymmetric synthesis of key intermediate for scytophycin C. Tetrahedron Lett. 2016, 57, 446.

13.Cui, J.; Lethu, S.; Yasuda, T.; Matsuoka, S.; Matsumori, N.; Sato, F.; Murata, M. Phosphatidylcholine bearing 6,6-dideuterated oleic acid: a useful solid-state 2H NMR probe for investigating membrane properties. Bioorg. Med. Chem. Lett. 2015, 25, 203.

14. Ando, J.; Kinoshita, M.; Cui, J.; Yamakoshi, H.; Dodoa, K.; Fujita, K.; Murata, M.; Sodeoka, M. Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy. Proc. Natl. Acad. Sci. USA, 2015, 112, 4558.

15.Cui, J.; Matsuoka, S.; Kinoshita, M.; Matsumori, N.; Sato, F.; Murata, M.; Ando, J.; Yamakoshi, H.; Dodo, K.; Sodeoka, M. Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior. Bioorg. Med. Chem. 2015, 23, 2989.

16.Cui, J.; Kawatake, S.; Umegawa, Y.; Lethu, S.; Yamagami, M.; Matsuoka, S.; Sato, F.; Matsumori, N.; Murata, M. Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions. Org. Biomol. Chem. 2015, 13, 10279.

主要荣誉

  2022,日本药学会(关东)青年科学家奖 

  2018,第九届国际功能有机化合物论坛(IFOC-9)最佳海报奖

  2015,日本学术振兴会(JSPS)特别研究员基金

  2012,日本文部科学省(MEXT)奖学金